Abstracts (first author)
Genomic scope of adaptive mutations to different environments
A panel of adaptive mutations was obtained by exposing Saccharomyces cerevisiae strains to harsh environmental conditions. The genomic scope of mutations allowing adaptation to these conditions was then determined by sequencing 35 different adapted lines from each of two environments. This panel was then used to measures trade-offs in different environments, as well as properties such as dominance across environments. The implications for Haldane's sieve and the role of ploidy in adaptation will be discussed.