Abstracts (first author)

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Determinants of protein evolutionary rates in light of ENCODE functional genomics

Author(s): Kryuchkova N, Robinson-Rechavi M

Summary:

The aim is to understand how the complex anatomy and developmental processes of animal influence the evolution of protein-coding genes.

The influence of different parameters, from gene size to expression levels, on the evolution of proteins has been previously studied in yeast, Drosophila and mammals. Here we investigate these relations further, especially taking in account gene expression and chromatin organization in different organs and different developmental stages. For expression we used a microarray experiment over zebrafish development as well as the RNA-seq data from ENCODE for 22 different tissues of mouse. We also used chromatin accessibility in mouse tissues, and we use ENCODE data to define which transcript is used as reference to compute gene length, intron number, etc. We find strong differences between tissues or developmental stages in impact of expression on evolutionary rate. Over all tissues, an interesting result is that evolutionary rate is better correlated with maximal expression in one tissue then with average expression value over all tissues.



Contacts

Chairman: Octávio S. Paulo
Tel: 00 351 217500614 direct
Tel: 00 351 217500000 ext22359
Fax: 00 351 217500028
email: mail@eseb2013.com

Address

XIV Congress of the European Society for Evolutionary Biology

Organization Team
Department of Animal Biology (DBA)
Faculty of Sciences of the University of Lisbon
P-1749-016 Lisbon
Portugal

Website

Computational Biology & Population Genomics Group 
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